Lower-grade glioma (LGG) is a group of tumors arising from the cells of the central
nervous system. Although various therapy interventions are used, the prognosis
remains different. Novel biomarkers are needed for the prognosis of disease and novel
therapeutic strategies in LGG. The procollagen-lysine, 2-oxoglutarate 5-dioxygenase
(PLOD) family contains three members and is related to multiple cancers, yet it was
not investigated in LGG. Data from the Chinese Glioma Genome Atlas (CGGA) and
The Cancer Genome Atlas (TCGA) cohorts were used to analyze the role of PLOD in
LGG. As the PLOD family is involved in processes, such as tumor formation and cancer
metastasis, we focused on its relationship to the tumor microenvironment (TME) in LGG.
A high expression of the PLOD family relates to poor prognosis and high infiltration of
immune cells within the TME. The expression level of the PLOD family might become a
novel biomarker for prognosis and is a potential target for individual treatment decisions
in LGG.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84564 |
| Date | 05 April 2023 |
| Creators | Gong, Siming, Wu, Changwu, Köhler, Franziska, Meixensberger, Jürgen, Schopow, Nikolas, Kallendrusch, Sonja |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1662-5102, 838548 |
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