Context: Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer’s disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected at the apical pole of acinar cells within the exocrine pancreas of mice and Bace1 activity was observed in pancreatic juice. In vitro experiments revealed enteropeptidase as a
putative substrate for Bace1 suggesting a role in acute pancreatitis.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-170593 |
| Date | 11 May 2015 |
| Creators | Heindl, Mario, Tuennemann, Jan, Sommerer, Ines, Mössner, Joachim, Hoffmeister, Albrecht |
| Contributors | Universitätsklinikum Leipzig, Department für Innere Medizin, Neurologie und Dermatologie, PLoS, |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article |
| Format | application/pdf |
| Source | PLoS one 2015, 10(5): e0125556 |
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