The major functions of glutathione S-transferase (Glutathione S-transferase; GST) include the maintenance of intracellular redox state of substances, and detoxification of cells of endogenous and exogenous toxic substances, and therefore GST plays an important physiological role.
The main purpose of this study is to find the effects of SjGST and morin on human breast cancer cell on growth and migration , and the possible mechanisms. Therefore we first carried out cell proliferation assays in vitro . Results showed that at low concentrations of SjGST could enhance the proliferation of breast cancer cell line MDA-MB435s better then high concentrations.And the cell migration assays results showen, when 36 and 48 hours that the low concentration SjGST can enhance the breast cancer cell line MDA-MB435s migration. Morin have antioxidant,anti-free radicals, and inhibitor of cancer cells growth. Therefore, we aimed at revealing the effect of more, GST and the mixture of both on growth and detoxination of MDA-MB435s. However, the results of detoxification assays shown,even add SjGST first or last or both mixed ,the concentration 5¡B10¡B50¡B100¡B200¡B500nM of SjGST still not protect the breast cancer cells (MDA-MB-435s cells line) to break away from morin .
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0112111-204002 |
| Date | 12 January 2011 |
| Creators | Lo, An-ju |
| Contributors | Hsiu-Moan Kuo, Huang, Hung-Tu, He,Shiping |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0112111-204002 |
| Rights | withheld, Copyright information available at source archive |
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