Pagrindinis šio darbo tikslas buvo susintetinti vandenyje tirpius norimos struktūros bei skirtingo pakeitimo laipsnio skiepytuosius chitozano-polietilenglikolio (MPEG) kopolimerus bei katijonizuotus chitozano darinius ir ištirti jų savybes. „Klik“ chemijos reakcijų pagalba susintetinti nauji įvairaus pakeitimo laipsnio chitozano-MPEG skiepytieji kopolimerai, turintys triazolilliekaną. Pasiūlyti nauji chitozano-C(6)-MPEG bei N-2,3-epoksipropil-N,N,N-trimetilamonio chloridu C(6)-katijonizuoto chitozano sintezės būdai, chitozano aminogrupių apsaugai naudojant chitozano kompleksus su dodecilsulfatu. Dalinai N-katijonizuoto chitozano darinius papildomai katijonizuojant šarminėje terpėje, gauti N,O-katijonizuoti chitozano dariniai, turintys labai didelį katijonizavimo laipsnį. Pasiūlytas katijonizuoto chitozano fermentinės hidrolizės metodas, kurį naudojant chitozano darinio molekulinę masę lengvai galima sumažinti dešimtimis kartų. Chitozaną modifikuojant vyno, citrinų, adipo rūgštimis, susintetinti dalinai tinklinti chitozano dariniai. Prie chitozano ir karboksirūgštimis modifikuotų chitozano nanodalelių prijungus (4-cianpentano rūgšties)-4-ditiobenzenkarboksilatą, susintetintas makroiniciatorius gyvybingajai radikalinei polimerizacijai RAFT metodu. / The main aim of this work was to synthesize water-soluble chitosan-methoxy poly(ethylene glycol) (MPEG) graft copolymers and quaternized derivative of chitosans of various structure and desirable graft density and to study their properties. Novel chitosan-MPEG derivatives containing triazolyl moiety with different degree of substitution of chitosan were prepared for the first time by “click chemistry”. Several new schemes of the synthesis of chitosan-C(6)-TMPEG and C(6)-quaternized chitosan derivatives were suggested based on protection of amino functionality by using chitosan-dodecyl sulfate complexes. Additional cationization of cationic chitosan through its hydroxyl groups in alkaline medium enabled to prepare N,O-quaternized chitosans derivatives with very high degree of quaternization. It was suggested method of enzymatic hydrolysis of quaternized chitosans which allow a tenfold decrease the molecular weight of chitosans derivatives. Modification of chitosan by tartaric, citric or adipic acid yielded partially crosslinked chitosan derivatives. Modification of chitosan and further modification of chitosan nanoparticles by dithiobenzendicarboxylate resulted in RAFT macroinitiators which are precursors of functionalized nanoparticles.
| Identifer | oai:union.ndltd.org:LABT_ETD/oai:elaba.lt:LT-eLABa-0001:E.02~2010~D_20100702_105142-18599 |
| Date | 02 July 2010 |
| Creators | Gruškienė, Rūta |
| Contributors | Tumkevičius, Sigitas, Malinauskas, Albertas, Dienys, Gervydas, Budrienė, Saulutė, Undzėnas, Algimantas, Žemaitaitis, Algirdas, Vareikis, Aušvydas, Makuška, Ričardas, Vilnius University |
| Publisher | Lithuanian Academic Libraries Network (LABT), Vilnius University |
| Source Sets | Lithuanian ETD submission system |
| Language | Lithuanian |
| Detected Language | Unknown |
| Type | Doctoral thesis |
| Format | application/pdf |
| Source | http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100702_105142-18599 |
| Rights | Unrestricted |
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