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Intravenous Self-Administration of Morphine by Naive Mice

A simple method for IV self-administration of drugs by mice is described. When morphine (0.5 mg/kg) was made contingent on a nosepoke response, naive mice increased their rate of nosepoking when compared either with animals receiving contingent saline vehicle injectionsor yoked control animals receiving noncontingent morphine.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-13834
Date01 January 1983
CreatorsCriswell, Hugh E., Ridings, Annette
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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