Exocrine pancreatic insufficiency (EPI) is a major complication of cystic fibrosis.
Conventional treatment involves the replacement of pancreatic enzymes and intake of a
low fat diet. However, contrary to previous therapeutic strategies, a high fat diet may be
beneficial in EPI patients. The present study investigated the effects of dietary
supplementation with Creon 10 000 a pancreatic enzyme preparation, in conjunction with
a high-fat diet, on growth performance, digestibility and absorption of fat in a pig model
of EPI by the surgical ligation of the pancreatic duct in 6 male pigs (Swedish Landrace X
Yorkshire X Hampshire). Following surgery, and for the duration of the experimental
period, pigs were fed a high fat diet (twice daily). The experimental period lasted for 15
days during which blood, urine and faecal samples were collected. In the last 7 days of
the experimental period (days 8-14), Creon 10 000 was included in the high fat meals.
Urine and faecal samples were analysed for dry matter, crude protein and fat content. Plasma was used to assess the lipaemic index and the plasma lipid profiles. Treatment
with Creon 10 000 significantly increased body mass (P = 0.016) and the digestibility of
dry matter, crude protein as well as the co-efficient of fat absorption were also
significantly improved following treatment (P<0.05). Creon 10 000 improved the
lipaemic index values and significant changes in plasma free fatty acid and triglyceride
concentrations were observed but not in cholesterol or high and low density lipoproteins.
This study supports previous reports that the administration of pancreatic enzyme
preparations together with a high fat meal is a beneficial strategy for the nutritional
management of EPI.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/6983 |
| Date | 26 May 2009 |
| Creators | Donaldson, Janine |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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