Laboratory mouse is a appropriate experimental model for studies on normal tooth development mechanisms and for understanding of etio-pathogenesis of dental anomalies in humans. Mouse dentition consists of one incisor separated from three molars by toothless diastema in each jaw quadrant. Although an adult mice diastema does not contain teeth, rudimentary tooth primordia (MS, R2) appear here during embryonic development. However, their development stops and consequently functional tooth does not arise here. It is known that in mice with mutations in Spry2 and Spry4 genes, supernumerary teeth arise in antemolar region. The understanding of the temporo-spatial dynamics of signaling centers in Spry2/Spry4 double transgenic mice may help to elucidate the role of these embryonic diastemal buds in supernumerary tooth formation. The research of possible regeneration of dental anomalies in off-spring of crossing Spry4 deficient mice with supernumerary teeth formation with Eda deficient mice with predisposition to reduced dentition could be the way to elucidating of mechanism of dental pathologies development in general. Our aim was to describe temporal and spatial dynamics of Shh signaling domains in Spry2/Spry4 embryos, because Shh is one of the markers of early odontogenesis and determining of...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:312521 |
| Date | January 2012 |
| Creators | Lochovská, Kateřina |
| Contributors | Hovořáková, Mária, Peterka, Miroslav |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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