Periodontitis is a chronic inflammatory condition affecting periodontal tissues, leading to gingival separation and destruction of the periodontal ligament and alveolar bone. Dysbiosis of the oral microbiome leads to microbial accumulation in the form of plaque. This subverts the immune system leading to local destruction and exacerbated inflammation. Daily activities such as tooth-brushing and eating can lead to bacteremia. In the context of periodontitis, dissemination of bacteria and inflammatory mediators increases the burden of systemic inflammation, complexifying noncommunicable diseases when comorbid. Periodontal therapy is relatively safe, minimally invasive, and known to reduce systemic levels of inflammatory markers. We can consider periodontal disease as a manageable risk factor and associate periodontal therapy with a wide range of health benefits. Associations between periodontitis and noncommunicable diseases have been established despite their high prevalence and shared similarities. While we can infer a biological relationship in many cases, more research is needed to establish effective interventions.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/45691 |
| Date | 22 February 2023 |
| Creators | Xu, Grace Chuyao |
| Contributors | McKnight, C. James, Fan, Xingjun |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | Attribution-NonCommercial-NoDerivatives 4.0 International, http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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