Since ancient times, indigenous plants have been used by traditional healers for treating
various ailments. Sutherlandia frutescens is one of the most commonly used medicinal plants
of southern Africa. This widely distributed plant has been traditionally used to treat cancer
and HIV patients; however scientific validation is still in high demand. This research aimed to
phytochemically characterise the various extracts prepared and to determine if any
chemotypes were present. Subsequent biological characterisation was carried out to
preliminary ascertain whether this medicinal plant could have anti-cancer and/or immunemodulating
properties and which compounds might be responsible for these actions.
Various traditional and organic extracts were prepared. Extracts, fractions and compounds
generated were analysed and chemical profiles obtained. Column chromatographic techniques
were used to isolate and purify compounds and structure elucidation was carried out using
various analytical techniques. Sulforhodamine B and cytometric bead array assays were
performed to determine the biological activities of samples generated. / Life and Consumer Sciences / (M. Sc. (Life Sciences)
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:unisa/oai:umkn-dsp01.int.unisa.ac.za:10500/5787 |
| Date | 06 1900 |
| Creators | Faleschini, Maria Teresa |
| Contributors | Meyer, M. S., Steenkamp, P. A., Dewar, J. B. |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Dissertation |
| Format | 1 online resource (xxi, 147 leaves.) |
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