Background: The role of the norepinephrine transporter (NET) has received increased focus
in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been
little-studied. This follow-up research on adult patients with ADHD aimed to explore whether the
therapy response and health and social impairments depend on baseline individual NET availability.
Methods: Data were collected from 10 patients on personal, family and professional situations, mental
and physical health and treatments received after baseline via online and telephone surveys and
were compared to baseline data to evaluate treatment-related changes. Results: The majority of our
ADHD patients did not show therapy responses but showed improvements due to pharmacological
treatment. There was no evidence of relationships between pre-treatment NET availability and
therapy response or health/social limitations. Conclusions: Pharmacological monotherapy was
insufficient to promote symptom remission, especially for participants with extreme insufficiency
in NET availability, but improved outcomes in academic and social functioning. Psychotherapy
should be considered as an add-on to the standard treatment approach due to its positive outcome
in reducing social limitations. The prognostic value of individual NET availability in predicting the
response to therapy needs further studies with large sample sizes
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:87810 |
| Date | 01 November 2023 |
| Creators | Huang, Jue, Mauche, Nicole, Rullmann, Michael, Ulke, Christine, Becker, Georg-Alexander, Patt, Marianne, Zientek, Franziska, Hesse, Swen, Sabri, Osama, Strauß, Maria |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English, German |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 965 |
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