Indiana University-Purdue University Indianapolis (IUPUI) / A study was made to develop a method for investigating
the quantity and location of vascular leakage during acute
inflammation of the dental pulp. Use was made of the method of
"vascular labelling" by which carbon particles placed in the
blood are deposited in the walls of leaking vessels. Three dogs
were used, with cavities of varying depth being cut in their
permanent teeth. Vascular leakage was induced in the skin and
in some of the teeth by applying histamine phosphate solution.
The tissues were studied in normal histologic sections and as
cleared specimens. It was found that the number of leaking vessels
was much less in the dental pulp than in the skin and that leakage
was confined to the area immediately below the cavity preparation
unless histamine had been applied to the cavity, when the labelled
vessels were found further apically. The number of leaking
vessels depended on the depth of the cavity, becoming greater as
the cavity depth increased. These findings would support the
common finding that the degree of inflammation beneath cavity
preparations increases with cavity depth. The conclusion was
that the method developed held promise as a tool in investigating
vascular changes in the dental pulp.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/4365 |
| Date | January 1966 |
| Creators | Page, James, 1939- |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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