Background Anthropometric measurements are useful in clinical practice since they are non-invasive and cheap. Previous studies suggest that sagittal abdominal diameter (SAD) may be a better measure of visceral fat depots. The aim of this study was to prospectively explore and compare how laboratory and anthropometric risk markers predicted subclinical organ damage in 255 patients, with type 2 diabetes, after four years. Methods Baseline investigations were performed in 2006 and were repeated at follow-up in 2010. Carotid intima-media thickness (IMT) was evaluated by ultrasonography and aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries at baseline and at follow-up in a cohort of subjects with type 2 diabetes aged 55–65 years old. Results There were significant correlations between apolipoprotein B (apoB) (r = 0.144, p = 0.03), C - reactive protein (CRP) (r = 0.172, p = 0.009) at baseline and IMT measured at follow-up. After adjustment for sex, age, treatment with statins and Hba1c, the associations remained statistically significant. HbA1c, total cholesterol or LDL-cholesterol did not correlate to IMT at follow-up. Baseline body mass index (BMI) (r = 0.130, p = 0.049), waist circumference (WC) (r = 0.147, p = 0.027) and sagittal Abdominal Diameter (SAD) (r = 0.184, p = 0.007) correlated to PWV at follow-up. Challenged with sex, SBP and HbA1c, the association between SAD, not WC nor BMI, and PWV remained statistically significant (p = 0.036). In a stepwise linear regression, entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV. Conclusions We conclude that apoB and CRP, but not LDL-cholesterol predicted subclinical atherosclerosis. Furthermore, SAD was more independent in predicting arterial stiffness over time, compared with WC, in middle-aged men and women with type 2 diabetes. / <p>Funding Agencies|Medical Research Council of Southeast Sweden||Center for Medical Image Science and Visualization (CMIV)||Linkoping University||Futurum||King Gustaf V and Queen Victoria Freemason Foundation||GE Healthcare||Swedish Heart-Lung Foundation||Swedish Research Council Grant|12661|</p>
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:liu-93864 |
| Date | January 2013 |
| Creators | Dahlén, Elsa, Bjarnegård, Niclas, Länne, Toste, Nyström, Fredrik H., Östgren, Carl Johan |
| Publisher | Linköpings universitet, Allmänmedicin, Linköpings universitet, Hälsouniversitetet, Linköpings universitet, Institutionen för medicin och hälsa, Linköpings universitet, Hälsouniversitetet, Linköpings universitet, Fysiologi, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Thorax-kärlkliniken i Östergötland, Linköpings universitet, Internmedicin, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Endokrin- och magtarmmedicinska kliniken US, Linköpings universitet, Allmänmedicin, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Vårdcentralen, BioMed Central |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Article in journal, info:eu-repo/semantics/article, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | Cardiovascular Diabetology, 1475-2840, 2013, 12, |
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