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Multimodální T2 kontrastní látky na bázi fluorescenčně značených magnetických jader spinelového typu pro zobrazování magnetickou rezonancí / Magnetic resonance imaging with multimodal T2 contrast agents based on fluorescence-labelled magnetic cores with the spinel structure

This diploma thesis was focused on the preparation of magnetic and fluorescently labelled spinel type nanoparticles, specifically nanoparticles of zinc-doped cobalt ferrite intended for application in magnetic resonance imaging and fluorescence microscopy in experimental practice. In previous studies, various ferrite nanoparticles exhibited relatively high transverse relaxation times and strong negative T2 contrast. These properties were also supposed for the zinc-doped cobalt ferrite nanoparticles. This assumption was confirmed by studying their magnetic and contrasting properties. Fluorescence properties of the prepared nanoparticles were also successfully studied. With respect to the intended applications of these particles, the issue of suitable surface modification of magnetic cores, their colloidal stabilization in an aqueous suspension and toxicity in biological systems were studied. Key words: nanoparticles, ferrites, MRI, relaxation

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:388731
Date January 2018
CreatorsKikerlová, Soňa
ContributorsKaman, Ondřej, Nižňanský, Daniel
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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