We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45%, 95%CI: -3.04, 11.93, p=0.244; Q=2.18, I(2)=0%). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p=0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p=0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51%, 95%CI: -25.13, 16.11, p=0.668; Q=6.41, I(2)=21.97%). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81%, 95%CI: -24.33, -1.30, p=0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p=0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p=0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels. / Revisión por pares
Identifer | oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/605887 |
Date | 30 March 2016 |
Creators | Dinca, Madalina, Serban, Maria-Corina, Sahebkar, Amirhossein, Mikhailidis, Dimitri P, Toth, Peter P, Martin, Seth S, Blaha, Michael J, Blüher, Matthias, Gurban, Camelia, Penson, Peter, Michos, Erin D, Hernandez, Adrian V., Jones, Steven R, Banach, Maciej |
Contributors | maciejbanach@aol.co.uk |
Publisher | Elsevier B.V. |
Source Sets | Universidad Peruana de Ciencias Aplicadas (UPC) |
Language | English |
Detected Language | English |
Type | info:eu-repo/semantics/article |
Format | application/pdf |
Source | Universidad Peruana de Ciencias Aplicadas (UPC), Repositorio Académico - UPC |
Rights | info:eu-repo/semantics/openAccess |
Relation | https://www.researchgate.net/profile/Maciej_Banach/publication/298064313_Does_vitamin_D_supplementation_alter_plasma_adipokines_concentrations_A_systematic_review_and_meta-analysis_of_randomized_controlled_trials/links/56fefd7008aee995dde73c14.pdf |
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