Thesis advisor: Kian L. Tan / The acceleration of catalytic asymmetric silylation of syn-diols and triols by use of an azole additive has been developed. By simply adding 7.5-20 mol % of a commercially available small-molecule, 5-ethylthiotetrazole, to a previously reported chiral catalyst, reactions proceed within one hour delivering the desired products with similarly high yields and enantiomeric ratios; there is minimal reaction during the same period when one of the co-catalysts is absent. In an attempt to better understand this silylation mechanism, computational catalyst design and synthetic development were employed. / Thesis (MS) — Boston College, 2013. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.
Identifer | oai:union.ndltd.org:BOSTON/oai:dlib.bc.edu:bc-ir_102044 |
Date | January 2013 |
Creators | Manville, Nathan Kyle |
Publisher | Boston College |
Source Sets | Boston College |
Language | English |
Detected Language | English |
Type | Text, thesis |
Format | electronic, application/pdf |
Rights | Copyright is held by the author, with all rights reserved, unless otherwise noted. |
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