The chemical constituents of organic extracts of a Formosan soft coral Sinularia lochmodes (Kolonko) (collected at Ken-Ting in Taiwan) was studied and isolated twelve nature compounds (1¡V12), including seven new compounds, lochmodesolides A¡VE (1¡V5), 4,6-dibromo-(2',5'-
dibromophenoxy) anisole (6), 3£],11-dihydroxy-5£],6£]-expoxy-24-
methylene-9,11-secocholestan-9-one (7), and five know compounds (8¡V12),(1R*,5R*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene-10,12-carbolactone (8), (1R*,
5S*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,
8-epoxycyclotetradec-12-ene-10,12-carbolactone (9), norcembrenolide 5 (10), scabrolides A (11), ineleganolide (12). The structures of 1¡V12 were elucidated by spectroscopic evidences (1D NMR, 2DNMR, IR and MS) and chemical method. The stereochemistry of compound 5 was further confirmed by single-crystal X-ray diffraction analyses.
Compounds 8 and 9 showed moderate cytotoxicity against KB, Hela, Med, NCI, DLD-1 and Hepa59T/VGH cancer cell lines.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0809104-153320 |
| Date | 09 August 2004 |
| Creators | Tseng, Yen-ju |
| Contributors | Yang-Chang Wu, Jyh-horng Sheu, none, Chang-Yih Duh |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0809104-153320 |
| Rights | not_available, Copyright information available at source archive |
Page generated in 0.0021 seconds