Knowledge about cardiac and inflammatory biomarkers in patients with stable coronary
artery disease (CAD) is limited. To address this, we analyzed 3072 patients (36% female) with a
median follow-up of 10 years in the Leipzig LIFE Heart Study with suspected CAD with coronary
angiography. Selected biomarkers included troponin T (hsTNT), N-terminal pro B-type natriuretic
peptide (NT-proBNP), copeptin, C-reactive protein (hsCRP), and interleukin-6 (IL-6). Patients were
stratified by CAD severity: CAD0 (no sclerosis), CAD1 (non-obstructive, i.e., stenosis < 50%), and
CAD2 (one stenosis 50%). Group comparison (GC) included GC1: CAD0 + 1 vs. CAD2; GC2:
CAD0 vs. CAD1 + 2. CAD0, CAD1, and CAD2 were apparent in 1271, 631, and 1170 patients,
respectively. Adjusted for classical risk factors, hs-cTnT, NT-proBNP, and IL-6 differed significantly
in both GC and hsCRP only in GC2. After multivariate analysis, hs-cTnT, NT-proBNP, and IL-6
remained significant in GC1. In GC2, hs-cTnT (p < 0.001) and copeptin (p = 0.014) reached significance.
Ten-year survival in groups CAD0, CAD1, and CAD2 was 88.3%, 77.3%, and 72.4%. Incorporation of
hs-cTnT, NT-proBNP, copeptin, and IL-6 improved risk prediction (p < 0.001). The studied cardiac
and inflammatory biomarkers enable fast and precise non-invasive identification of mortality risk in
CAD patients, allowing the tailoring of primary and secondary CAD prevention.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89007 |
| Date | 15 January 2024 |
| Creators | Netto, Jeffrey, Teren, Andrej, Burkhardt, Ralph, Willenberg, Anja, Beutner, Frank, Henger, Sylvia, Schuler, Gerhard, Thiele, Holger, Isermann, Berend, Thiery, Joachim, Scholz, Markus, Kaiser, Thorsten |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3433 |
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