Title page, contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for significant morbidity and mortality worldwide. Pneumococcal disease, which can include both invasive conditions such as pneumonia, bacteremia and meningitis, as well as less severe conditions such as otitis media, is almost invariably preceded by asymptomatic colonisation of the nasopharynx. To successfully adapt to the different ecological niches it encounters, the pneumococcus is likely to rely on the co-ordinated regulation of key virulence factors. As is the case for many other prokaryotes, this is likely to occur through two-component signal transduction systems (TCSTSs). TCSTSs comprise a histidine kinase (HK) and response regulator (RR). They respond to environmental stimuli, and regulate gene expression by interacting with the transcription machinery. Thirteen complete TCSTSs have been identified in S. pneumoniae, along with a lone RR. This study focused on one of these systems, designated RR/HK06. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1255323 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2006
| Identifer | oai:union.ndltd.org:ADTP/280364 |
| Date | January 2006 |
| Creators | Standish, Alistair James |
| Source Sets | Australiasian Digital Theses Program |
| Detected Language | English |
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