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Light shed on a non-canonical TCA cycle: cell state regulation beyond mitochondrial energy production

In this recent study,1 the authors analyzed the metabolic gene essentiality scores from genome-wide loss of function CRISPR screens in 769 human cancer cell lines and noticed that TCA cycle-associated genes clustered in two separate groups: one forming the traditional TCA cycle and another related to a non-canonical TCA cycle module. They monitored both modules with elegant tracing studies using [U-13C]glucose which generates citrate labeled with two 13C atoms (M+2).

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:91310
Date22 May 2024
CreatorsMateska, Ivona, Alexaki, Vasileia
PublisherMacmillan Publishers, part of Springer Nature
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text
Rightsinfo:eu-repo/semantics/openAccess
Relation201, 10.1038/s41392-022-01060-5

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