Background: This study compared patient profiles and clinical courses of
SARS-CoV-2 infected inpatients over different pandemic periods.
Methods: In a retrospective cross-sectional analysis, we examined
administrative data of German Helios hospitals using ICD-10-codes at
discharge. Inpatient cases with SARS-CoV-2 infection admitted between
03/04/2020 and 07/19/2022 were included irrespective of the reason for
hospitalization. All endpoints were timely assigned to admission date for trend
analysis. The first pandemic wave was defined by change points in time-series
of incident daily infections and compared with different later pandemic phases
according to virus type predominance.
Results: We included 72,459 inpatient cases. Patients hospitalized during the
first pandemic wave (03/04/2020–05/05/2020; n = 1,803) were older (68.5 ±
17.2 vs. 64.4±22.6 years, p<0.01) and severe acute respiratory infections were
more prevalent (85.2 vs. 53.3%, p < 0.01). No differences were observed with
respect to distribution of sex, but comorbidity burden was higher in the first
pandemic wave. The risk of receiving intensive care therapy was reduced in all
later pandemic phases as was in-hospital mortality when compared to the first
pandemic wave. Trend analysis revealed declines of mean age and Elixhauser
comorbidity index over time as well as a decline of the utilization of intensive
care therapy, mechanical ventilation and in-hospital mortality.
Conclusion: Characteristics and outcomes of inpatients with SARS-CoV-2
infection changed throughout the observational period. An ongoing evaluation
of trends and care pathways will allow for the assessment of future demands
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:91368 |
| Date | 14 May 2024 |
| Creators | König, Sebastian, Hohenstein, Sven, Pellissier, Vincent, Leiner, Johannes, Hindricks, Gerhard, Nachtigall, Irit, Kuhlen, Ralf, Bollmann, Andreas |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1028062 |
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