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Previous issue date: 2012-02-16 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The correct histological diagnosis of vascular lesions in the oral mucosa is
critical, especially in defining the treatment and prognosis, as some vascular lesions
show spontaneous involution and others do not show such behavior. This study
analyzed the expression immunohistochemistry of human glucose transporter protein
(GLUT-1), in oral benign vascular tumors and to reclassify such lesions according to
with his immunoexpression. In addition, we evaluated the immunohistochemical
expression of hypoxia-inducible factor 1 alpha (HIF-1?), the main transcription factor
involved in cellular adaptation to hypoxia. We analyzed 60 cases of benign oral vascular
tumors: 30 cases with histological diagnosis of HEM and 30 cases of oral pyogenic
granuloma (PG). The results of this research showed that of the 30 lesions initially
classified as HEM, only 7 showed immuno-positivity for GLUT-1, remaining with the
initial diagnosis. The remaining 23 were reclassified as vascular malformation (VM)
(13 cases) and PG (10 cases). All cases in the sample with an initial diagnosis of PG
were negative for GLUT-1, demonstrating the accuracy of histological diagnosis of
these lesions. Concerning to the immunoexpression of HIF-1?, the Mann-Whitney test
revealed a statistically significant difference between the cases of GP and MV (p =
0.002), where the median of GP (m=78) was higher than the MV (m=53). Based on
these results, this study showed that a histological diagnosis alone is not always
sufficient for the correct diagnosis of oral HEM and that HIF-1? participates in the
pathogenesis of vascular lesions / O correto diagn?stico histol?gico de les?es vasculares em mucosa oral ?
fundamental, sobretudo na hora de definir o tratamento e progn?stico, visto que
algumas dessas les?es apresentam involu??o. Este trabalho analisou a express?o imunohistoqu?mica
da prote?na humana transportadora de glicose (GLUT-1), em tumores
vasculares benignos orais e reclassificou tais les?es de acordo com sua imunoexpress?o.
Al?m disso, avaliou a express?o imuno-histoqu?mica do fator 1 induz?vel por hip?xia
(HIF-1?), principal fator de transcri??o envolvido na adapta??o celular ? hip?xia. Foram
analisados 60 casos de tumores vasculares benignos orais, sendo 30 casos com
diagn?stico histol?gico de HEM e 30 casos de granulomas piog?nicos orais (GP). Os
resultados desta pesquisa demonstraram que das 30 les?es inicialmente classificadas
como HEM, apenas 7 apresentaram imuno-positividade para GLUT-1, permanecendo
com o diagn?stico inicial. As 23 restantes foram reclassificadas em malforma??o
vascular (MV) 13 casos e GP 10 casos . Todos os casos da amostra com diagn?stico
inicial de GP apresentaram-se negativos para GLUT-1. Quanto ? imunoexpress?o do
HIF-1?, o teste de Mann-Whitney revelou diferen?a estatisticamente significativa entre
os casos de GP e MV(p=0,002), onde a mediana do GP (m=78) foi superior a da MV
(m=53). Com base nesses resultados, este estudo mostrou que o diagn?stico histol?gico
por si s? nem sempre ? suficiente para o diagn?stico correto do HEM oral e que o HIF-
1? participa da patog?nese das les?es vasculares
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17117 |
| Date | 16 February 2012 |
| Creators | Oliveira, Denise H?len Imaculada Pereira de |
| Contributors | CPF:59539224420, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4793681A0&dataRevisao=null, Alves, Pollianna Muniz, CPF:03088272446, http://lattes.cnpq.br/4860117599607892, Silveira, Ericka Janine Dantas da, CPF:02869049420, http://lattes.cnpq.br/2186658404241838, Queiroz, L?lia Maria Guedes |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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