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Previous issue date: 2012-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / A candis?ase vulvovaginal (CVV) ? uma doen?a inflamat?ria, no tecido vaginal,
causada principalmente por leveduras patog?nicas de Candida albicans. E
atualmente CVV ? um problema significativo na sa?de da mulher. As ? glucanas s?o
polissacar?deos estruturais da parede celular da levedura Saccharomyces cerevisiae
e existem v?rios relatos que demonstram o efeito imunomodulador desta estrutura
em infec??es bacterianas, virais, f?ngicas e parasit?rias. Sabendo disso, o presente
estudo avaliou se a ?-glucana tem atividade imunomoduladora em camundongos
com candid?ase vulvovaginal sob a influ?ncia do estr?geno. Os animais foram
inoculados com C. albicans, por via intravaginal, e tratados com glucana, vaginal e
intraperitonealmente, e os animais do grupo de controle receberam por via
intraperitoneal, solu??o salina. Os animais tratados com glucana intraperitoneal e
vaginal mostraram menor n?mero de UFC, no fluido vaginal, em compara??o com
animais controles. No entanto, os resultados mais marcantes foram do
intraperitoneal, confirmando com o histopatol?gico, por?m sem diferen?a
estatisticamente significante. Em rela??o ao influxo dos neutr?filos
polimorfonucleares (PMNs), os grupos tratados com glucana mostraram maior
infiltra??o desses. Al?m disso, observou-se que os animais tratados com glucana
apresentaram uma maior quantidade de IFN-?, no lavado vaginal, em compara??o
com o controle. Os dados sugerem que glucana pode ter uma atividade importante
na prote??o contra C. albicans. / Vulvovaginal candidiasis (VVC) is an inflammatory disease, on vaginal tissue, caused
mainly by pathogenic yeasts of Candida albicans. And actually, VVC is currently a
significant problem in women's health. The ?-glucans are structural polysaccharides
of the cell wall of the fungi Saccharomyces cerevisiae and there are several reports
that demonstrate the immunomodulatory effect this structure in infections of bacterial,
viral, fungal and parasitic. Knowing this, the present study evaluated whether ?-
glucan has immunomodulatory activity in mice with vulvovaginal candidiasis under
the influence of estrogen. The animals were inoculated with C. albicans,
intravaginally, and treated with glucan, vaginally and intraperitoneally, and the control
group animals received saline, intraperitoneally. The animals treated with
intraperitoneal and vaginal glucan showed smaller number of the CFU, in the vaginal
fluid, compared with control animals. However the results more marked was of the
intraperitonel, confirmed with histopathological, but in neither case the results were
statistically significant. Relative to influx of the polymorphonuclear neutrophilis
(PMNs), the groups treated with glucan showed greater infiltration. Moreover, it was
observed that animals treated with glucan showed a higher quantity of IFN-?, in
vaginal washed, compared with the control. The data suggest that glucan may have
an important activity in protection against C. albicans.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/24440 |
| Date | 27 February 2012 |
| Creators | Lima, Aleida Maria da Silva |
| Contributors | 25069144472, Machado, Paula Renata Lima, 69508950200, Svidzinski, Terezinha Inez Estivalet, 32224010982, Chaves, Guilherme Maranh?o, Sales, Val?ria Soraya de Farias |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMAC?UTICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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