Zinc is an essential element that has many important functions in our organism. The objective of the thesis is to verify the effect of dietary zinc nanocomplexes as an alternative source of zinc for the animal organism. For the experimental model of this experiment male rats of the outbred strain Wistar albino were used. The rats were divided into 3 groups. Six males were housed in each group. The first group (control) (n = 6) of the rats served as a control one and the zinc dose was not increased. The second group (Zn-EDT) of animals (n = 6) was dosed with zinc nanoparticles (200 mg/kg diet). The third group (Zn-NTA) of rats (n = 6) was dosed with zinc in the form of zinc nanoparticles (200 mg/kg diet). The rats were sacrificed after 15 days of experimentation. The animals samples of erythrocytes and liver were extracted and subjected to appropriate analyses immediately after collection. Antioxidant activity was analysed using FR and DPPH methods, SOD activity, metallothionein and zinc concentration. The results show that the antioxidant capacity in the erythrocytes decreased statistically in Zn-NTA (P < 0.05). The concentration of zinc in erythrocytes has increased inconclusively. There was a statistically significant increase (P < 0.05) of metallothionein in the liver.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:430147 |
| Date | January 2017 |
| Creators | Konvalinová, Žaneta |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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