Yes / Context: Vitamin D is essential for bone health in adolescence, where there is rapid bone mineral
content accrual. As cutaneous sun-exposure provides vitamin D, there is no recommended oral intake
for UK adolescents.
Assess seasonal vitamin D status and its contributors in white Caucasian adolescents, and
examine bone health in those found deficient.
Design: Prospective cohort study.
Setting: Six schools in Greater Manchester, UK.
Participants: 131 adolescents, 12–15 years.
Intervention(s): Seasonal assessment of circulating 25-hydroxyvitamin D (25OHD), personal sunexposure
and dietary vitamin D. Adolescents deficient (25OHD <10 ng/mL/25 nmol/L) in ≥one
season underwent dual-energy X-ray absorptiometry (lumbar spine, femoral neck), with bone mineral
apparent density (BMAD) correction for size, and peripheral quantitative computed tomography
(distal radius) for volumetric (v)BMD.
Main Outcome Measure: Serum 25OHD; BMD.
Results: Mean 25OHD was highest in September: 24.1 (SD 6.9) ng/mL and lowest in January: 15.5
(5.9) ng/mL. Over the year, 16% were deficient in ≥one season and 79% insufficient (25OHD <20
ng/mL/50 nmol/L) including 28% in September. Dietary vitamin D was low year-round while
personal sun-exposure was seasonal and predominantly across the school week. Holidays accounted
for 17% variation in peak 25OHD (p<0.001). Nineteen adolescents underwent bone assessment,
which showed low femoral neck BMAD versus matched reference data (p=0.0002), 3 with Z≤ -2.0
distal radius trabecular vBMD.
Conclusions: Sun-exposure levels failed to provide adequate vitamin D, ~one-quarter adolescents
insufficient even at summer-peak. Seasonal vitamin D deficiency was prevalent and those affected
had low BMD. Recommendations on vitamin D acquisition are indicated in this age-group. / The Bupa Foundation (Grant number TBF-M10-017).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/14541 |
| Date | 01 August 2016 |
| Creators | Farrar, M.D., Mughal, M.Z., Adams, Jenny E., Wilkinson, J., Berry, J.L., Edwards, Lisa, Kift, R., Marjanovic, E., Vail, A., Webb, A.R., Rhodes, L.E. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2016 by the Endocrine Society. Reproduced in accordance with the publisher's self-archiving policy. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The definitive publisherauthenticated version [Farrar MD, Mughal MZ, Adams JE et al (2016) Sun exposure behaviour, seasonal vitamin D deficiency, and relationship to bone health in adolescents. The Journal of Clinical Endocrinology & Metabolism. 101(8): 3105-3113.] is available online at: https://doi.org/10.1210/jc.2016-1559 |
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