Yes / New multicomponent solid forms of sildenafil have been discovered
by means of a combined virtual/experimental cocrystal screening. Coformer
selection of candidates was conducted based on an in silico screening method from
a database of more than 2000 organic compounds, and the intensive experimental
screen produced 23 new solid forms. Since the 12 coformers chosen have a
combination of phenol and carboxylic acid groups, a variety of cocrystals, salts, and
hybrid salt-cocrystals were discovered and characterized.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/16663 |
| Date | 30 October 2018 |
| Creators | Barbas, R., Font-Bardia, M., Paradkar, Anant R, Hunter, C.A., Prohens, R. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted Manuscript |
| Rights | © 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.cgd.8b01413 |
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