No / Pharmaceutical tablets have been the most dominant form for drug delivery and most of them are used in
the oral administration of drugs. These tablets need to be strong enough so that they can tolerate external
stresses. Hence, during the design process, it is important to produce tablets with maximum mechanical
strength while conserving the properties of powder form components. The mechanical properties of
these tablets are assessed by measuring the tensile strength, which is commonly measured using diametrical
or axial compression tests.
This work describes the parametric design and optimisation of solid pharmaceutical tablets in cylindrical
and spherical shapes, which are obtained using a formulation based on the use of Partial Differential
Equations (PDEs) for shape design. The PDE-based formulation is capable of parameterised complex
shapes using the information from some boundary curves that describe the shape. It is shown that the
optimal design of pharmaceutical tablets with a particular volume and maximum strength can be
obtained using an automatic design optimisation which is performed by combining the PDE method
and a standard method for numerical optimisation.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/8169 |
| Date | 11 October 2013 |
| Creators | Ahmat, Norhayati, Gonzalez Castro, Gabriela, Ugail, Hassan |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text available in the repository |
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