Background:
This prospective study was conducted to assess changes in quality of life (QoL) of patients who undergo a partial laryngectomy (PLE).
Methods:
The European Organization for Research and Treatment of Cancer questionnaires QLQ-C30 and QLQ-H&N35 were used pre-procedure (n=218), one week (n=159), three months (n=122) and one year after PLE (n=88). Changes over time were analyzed with the Wilcoxon-signed-rank-test and the Holm-Bonferroni-method, and interpreted regarding clinical relevance.
Results:
Most subscales worsened one week post-procedure, but many recovered to baseline level after one year. Dyspnea and cognitive functioning deteriorated over time, with worst scores recorded after one year. Financial difficulties and fatigue increased after surgery and maintained that level throughout the follow-up period; sticky saliva remained worse than at baseline, despite some improvements over time.
Conclusions:
The discovered limitations of QoL should be observed more closely during follow-up treatment, and patients should be informed about these potential eaffects before PLE.:1 Einführung ........................................................................................................... 3
1.1 Das Larynxkarzinom ......................................................................................... 3
1.2 Therapiemöglichkeiten des Larynxkarzinoms ................................................... 4
1.3 Lebensqualität ................................................................................................... 5
1.4 Methodik bei der Evaluierung von Lebensqualität ............................................. 7
1.5 Lebensqualität bei Krebspatienten .................................................................... 8
1.6 Lebensqualität nach Therapie von Kopf-Hals-Tumoren .................................. 10
2 Zielstellung der Studie ....................................................................................... 13
3 Publikation ......................................................................................................... 14
4 Zusammenfassung ............................................................................................ 37
4.1 Einführung....................................................................................................... 38
4.2 Methoden ........................................................................................................ 39
4.3 Ergebnisse ...................................................................................................... 39
4.4 Diskussion....................................................................................................... 41
5 Literaturverzeichnis ............................................................................................ 44
6 Anlagen ............................................................................................................. 49
6.1 Darstellung des eigenen Beitrags ................................................................... 49
6.2 Selbstständigkeitserklärung ............................................................................ 50
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:36245 |
| Date | 25 November 2019 |
| Creators | Clasen, Daniel |
| Contributors | Kersting, Anette, Mehnert, Anja, Hinz, Andreas, Keszte, Judith, Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | German, English |
| Detected Language | English |
| Type | info:eu-repo/semantics/acceptedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | https://doi.org/10.1002/hed.25095 |
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