Objective: This study presumed that a high or low bodymass index (BMI)might increase
the risk of infant mortality. Therefore, a meta-analysis was performed to systematically
assess the association between maternal BMI and the risk of infant mortality.
Methods: The electronic databases, including Pubmed, Embase database, and
Cochrane Library, were systemically searched by two investigators from inception
to November 26th, 2020, with no language restriction. In parallel, a dose-response
was assessed.
Results: Finally, 22 cohort studies involving 13,532,293 participants were included
into this paper, which showed that compared with normal BMI, maternal overweight
significantly increased the risks of infant mortality [risk ratio (RR), 1.16; 95% confidence
interval (CI), 1.13–1.19], neonatal mortality (RR, 1.23; 95% CI, 1.08–1.39), early neonatal
mortality (RR, 1.55; 95% CI, 1.26–1.92) and post-neonatal mortality (RR, 1.18; 95% CI,
1.07–1.29). Similarly, maternal obesity significantly increased the risk of infant mortality
(RR, 1.55; 95% CI, 1.41–1.70), neonatal mortality (RR, 1.55; 95% CI, 1.28–1.67), early
neonatal mortality (RR, 1.37; 95% CI, 1.13–1.67), and post-neonatal mortality (RR, 1.30;
95% CI, 1.03–1.65), whereas maternal underweight potentially decreased the risk of
infant mortality (RR, 0.93; 95% CI, 0.88–0.98). In the dose-response analysis, the risk of
infant mortality significantly increased when the maternal BMI was >25 kg/m2.
Conclusions: Maternal overweight or obesity significantly increases the risks of
infant mortality, neonatal mortality, early neonatal mortality, and post-neonatal mortality
compared with normal BMI in a dose-dependentmanner. Besides,maternal underweight
will not increase the risk of infant mortality, neonatal mortality, early neonatal mortality, or
postneonatal mortality; instead, it tends to decrease the risk of infant mortality. Early
weight management may provide potential benefits to infants, and more large-scale
prospective studies are needed to verify this finding in the future.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84403 |
| Date | 30 March 2023 |
| Creators | Huo, Nana, Zhang, Kun, Wang, Li, Wang, Lina, Lv, Wenhu, Cheng, Wenke, Jia, GuangZhu |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2296-2360, 650413 |
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