Mesenchymal stromal cells (MSC) represent a promising treatment option for tendon
disorders and joint diseases, primarily osteoarthritis. Since MSC are highly context-sensitive to their microenvironment, their therapeutic efficacy is influenced by their
tissue-specific pathologically altered targets. These include not only cellular
components, such as resident cells and invading immunocompetent cells, but also
components of the tissue-characteristic extracellular matrix. Although numerous in vitro
models have already shown potential MSC-related mechanisms of action in tendon and
joint diseases, only a limited number reflect the disease-specific microenvironment and
allow conclusions about well-directed MSC-based therapies for injured tendon and joint-associated tissues. In both injured tissue types, inflammatory processes play a pivotal
pathophysiological role. In this context, MSC-mediated macrophage modulation seems to
be an important mode of action across these tissues. Additional target cells of MSC
applied in tendon and joint disorders include tenocytes, synoviocytes as well as other
invading and resident immune cells. It remains of critical importance whether the context-sensitive interplay between MSC and tissue- and disease-specific targets results in an
overall promotion or inhibition of the desired therapeutic effects. This review presents the
authors’ viewpoint on disease-related targets of MSC therapeutically applied in tendon and
joint diseases, focusing on the equine patient as valid animal model.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:85860 |
| Date | 08 June 2023 |
| Creators | Roth, Susanne Pauline, Burk, Janina, Brehm, Walter, Troillet, Antonia |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 855095 |
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