Pattern recognition receptors (e.g., S100A12 or S100A8/A9) hold promise as inflammatory biomarkers. We
prospectively determined and compared serum S100A12 and S100A8/A9 concentrations in dogs with sepsis (n = 11) or
systemic inflammatory response syndrome (SIRS; n = 8) over a 3-d period with each other, healthy controls (n = 50), and other
clinical and clinicopathologic variables. Serum S100A12 and S100A8/A9 concentrations were significantly higher in dogs
with sepsis or SIRS (all p < 0.05) at the time of hospital admission (day 1) compared to healthy controls, with no differences
between patient groups. However, septic dogs had significantly lower serum S100A12 concentrations on day 2 and day 3 (both
p < 0.05) compared to dogs with SIRS. Likewise, dogs with sepsis had significantly lower S100A8/A9 concentrations on day
2 (p < 0.05). Neither serum S100A12 nor S100A8/A9 concentrations were associated with survival to discharge. Our results
suggest a differential expression of the S100/calgranulins between dogs with sepsis and those with SIRS. Serum S100A12 or
S100A8/A9 concentration at the time of hospital admission did not differentiate dogs with sepsis from those with SIRS, but
the trend of S100/calgranulin concentrations during the following 24–48 h may be a useful surrogate marker for differentiating
sepsis from SIRS.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:86434 |
| Date | 11 July 2023 |
| Creators | Thames, Brittany E., Barr, James W., Suchodolski, Jan S., Steiner, Jörg M., Heilmann, Romy M. |
| Publisher | Sage Publications |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1040-6387 |
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