Cutaneous lupus erythematosus (CLE) represents a complex autoimmune
disease with a broad phenotypic spectrum ranging from acute to chronic
destructive cutaneous lesions. Patients with CLE exhibit high photosensitivity
and ultraviolet (UV) irradiation can lead to systemic flares in systemic
lupus erythematosus. However, the exact mechanisms how UV irradiation
enhances cutaneous inflammation in lupus are not fully understood. Recently,
new molecular mechanisms of UV-driven immune responses in CLE were
identified, offering potential therapeutic approaches. Especially the induction
of type I interferons, central cytokines in lupus pathogenesis which are
released by various skin cells, have become the focus of current research.
In this review, we describe current pathogenic concepts of photosensitivity in
lupus erythematosus, including UV-driven activation of intracellular nucleic
acid sensors, cellular cytokine production and immune cell activation.
Furthermore, we discuss activated pathways contributing to enhanced
apoptosis as well as intracellular translocation of autoantigens thereby
promoting CLE upon UV light exposure.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88337 |
| Date | 28 November 2023 |
| Creators | Klein, Benjamin, Kunz, Manfred |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 939594 |
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