Establishing highly sophisticated polymer films for delivery systems in a biological environment and bioanalytical tasks, the formation, thickness, swelling behavior, and (physiological) stability of highly biocompatible polyelectrolyte multilayers (PEMs) are described. These PEMs are composed of the very weak polycation maltose-modified hyperbranched poly(ethyleneimine) (PEI-Mal), strongly polyanion heparin sodium salt (HE − Na +) or weakly charged polyanion hyaluronic acid sodium salt (HA-Na+) deposited on Si wafer substrates.
Two different glyco architectures for PEI-Mal are used, characterized by two different degrees of maltose decoration on a PEI scaffold. Using three pH-dependent deposition approaches for optimizing the (physiological) PEM stability and swelling, PEMs are characterized by (in situ) ellipsometry, atomic force microscopy (AFM), and (in situ) attenuated total reflection-Fouriertransform infrared (ATR-FTIR).
Thus, PEMs reveal significantly different thicknesses, growth mechanisms (linear versus exponential), and swelling behavior in dependence of both the polycation architectures and the deposition protocol. These PEMs will allow the study of their complexation and release properties as preswollen PEMs against anionic drug molecules, adenosine triphosphate sodium salt (ATP), especially under physiological conditions for future drug delivery coatings.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:14-qucosa-172713 |
| Date | 08 July 2015 |
| Creators | Salem, Samaa |
| Contributors | Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften, Prof. Dr. Brigitte Voit, Prof. Dr. Brigitte Voit, Prof. Dr. Regine v. Klitzing |
| Publisher | Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:doctoralThesis |
| Format | application/pdf |
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