The microbiota has a strong influence on health and disease in humans. A causative shift favoring pathobionts is strongly linked to diseases. Therefore, anti-microbial agents selectively targeting potential pathogens as well as their biofilms are urgently demanded. Here we demonstrate the impact of ethyl pyruvate, so far known as ROS scavenger and antiinflammatory agent, on planktonic microbes and biofilms. Ethyl pyruvate combats preferably the growth of pathobionts belonging to bacteria and fungi independent of the genera and prevailing drug resistance. Surprisingly, this anti-microbial agent preserves symbionts like Lactobacillus species. Moreover, ethyl pyruvate prevents the formation of biofilms and promotes matured biofilms dissolution. This potentially new anti-microbial and anti-biofilm
agent could have a tremendous positive impact on human, veterinary medicine and technical industry as well.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-212525 |
| Date | 27 October 2016 |
| Creators | Debebe, Tewodros, Krüger, Monika, Huse, Klaus, Kacza, Johannes, Mühlberg, Katja, König, Brigitte, Birkenmeier, Gerd |
| Contributors | Universität Leipzig, Medizinische Fakultät, Universität Leipzig, Fakultät für Biowissenschaften, Pharmazie und Psychologie, Universität Leipzig, Veterinärmedizinische Fakultät, Leibniz-Institut für Alternsforschung,, Universität Leipzig, Veterinärmedizinische Fakultät, Universität Leipzig, Medizinische Fakultät, Bahir Dar University, College of Medicine and Health Sciences, Public Library of Science, |
| Publisher | Universitätsbibliothek Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:article |
| Format | application/pdf |
| Source | PLoS ONE 11(9): e0162919 doi:10.1371/journal.pone.0162919 |
Page generated in 0.002 seconds