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Previous issue date: 2016-06-14 / Osteoporosis (OP) is a common osteometabolic disease among the elderly and
may be associated with genetic components that influence bone metabolism.
Due to regulatory action of vitamin D in osteomineral physiology, the expression
of the vitamin D receptor gene (VDR) in bone tissue, it is able to influence the
genetic determinants of bone mineral density (BMD) and the OP. Studies report
the existence of polymorphisms related to the pathogenesis of OP, which can
lead to changes in the mechanisms of the action of vitamin D. The BsmI and
FokI polymorphisms were associated with changes in BMD suggesting thus a
higher incidence and prevalence of fractures due to bone fragility. The objective
of this study was to associate the presence of BsmI and FokI polymorphisms
located in VDR gene, serum levels of 25(OH)D and susceptibility to OP for
elderly women. It was observed that 58% of the study sample had levels of
25(OH)D below the threshold considered sufficient and 62% showed changes in
BMD values consistent with the diagnosis of osteopenia or osteoporosis. For
elderly women, vitamin D levels are not related to the reduction of BMD and
presence of polymorphisms. In the evaluation of polymorphic sites it was found
that, in this sample, 28% were positive for FokI polymorphism and 10% were
positive for BsmI. The described results show that in elderly women, the BsmI
polymorphisms FokI and are not related to vitamin D and osteoporosis. / A osteoporose (OP) ?? uma afec????o osteometab??lica comum em idosos,
associada ou n??o a componentes gen??ticos que influenciam no metabolismo
??sseo. Devido ?? a????o reguladora da vitamina D na fisiologia osteomineral, a
express??o do gene receptor da vitamina D (VDR) no tecido ??sseo ?? capaz de
exercer influ??ncia na determina????o gen??tica da densidade mineral ??ssea
(DMO) e OP. Estudos reportam a exist??ncia de polimorfismos relacionados
com a etiopatogenia da OP os quais podem determinar altera????es nos
mecanismos de a????o da vitamina D. Os polimorfismos BsmI e FokI foram
associados com varia????es na DMO sugerindo uma maior incid??ncia e
preval??ncia de fraturas por fragilidade ??ssea. Desta forma, o objetivo deste
estudo foi associar a presen??a dos polimorfismos BsmI e FokI localizados no
gene VDR, as concentra????es s??ricas de 25-hidroxivitamina D (25(OH)D) e a
susceptibilidade ?? osteoporose em idosas. Para tanto, foram inclu??das 50
idosas com m??dia de idade de 71,74 ?? 7,80 anos (60 ??? 94 anos). Os
polimorfismos BsmI e FokI foram pesquisados e os dados sobre os n??veis de
25(OH)D e DMO foram coletados mediante acompanhamento ambulatorial.
Observou-se que 58% da amostra estudada possui n??veis de 25(OH)D abaixo
do limiar considerado suficiente e 62% apresentaram altera????es nos valores
de DMO compat??veis com o diagn??stico de osteopenia ou osteoporose. Nas
idosas avaliadas os n??veis de vitamina D n??o est??o relacionados com a
redu????o da DMO e presen??a dos polimorfismos. Na avalia????o dos s??tios
polim??rficos verificou-se que, nessa amostra, 28% apresentaram resultado
positivo para o polimorfismo FokI e 10% apresentaram positividade para BsmI.
Os resultados descritos evidenciam que, nas idosas avaliadas, os
polimorfismos BsmI e FokI n??o se encontram relacionados com os n??veis de
vitamina D e osteoporose.
| Identifer | oai:union.ndltd.org:IBICT/oai:bdtd.ucb.br:tede/2171 |
| Date | 14 June 2016 |
| Creators | Ramos, Rafaela |
| Contributors | Vila??a, Karla Helena Coelho, Mascarenhas, Cintia do Couto |
| Publisher | Universidade Cat??lica de Bras??lia, Programa Strictu Sensu em Gerontologia, UCB, Brasil, Escola de Sa??de e Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UCB, instname:Universidade Católica de Brasília, instacron:UCB |
| Rights | info:eu-repo/semantics/openAccess |
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