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Previous issue date: 2012-04-17 / Background: The number of elderly (60 years or more) grows all over the world, for two
reasons: increased life expectancy and reducing fertility rates. Furthermore, cardiovascular
diseases, particularly atherosclerosis, are the major cause of death in the elderly people.
Aging causes changes in the immune system that contribute to a higher incidence of
infectious diseases and chronic degenerative diseases. Increased basal levels of cytokines,
represent a systemic chronic inflammatory state known Inflammation. In the elderly, the
redistribution of tissue calcification is different from the predictive value of coronary artery
calcification. Thus, the association of comorbidities caused by aging prevents the
extrapolation of knowledge gained in younger populations. Main: To investigate the
relantionship between serum levels of cytokines: TNF- , IL-10 and C-Reactive Protein
(CRP) with coronary calcification in the very elderly. Materials and methods: Individuals
aged between 80 and 102 years (n = 178). Was evaluated plasma cytokines, acute phase
proteins, intima-media thickness (IMT), presence of plaques in the carotid arteries by
ultrasound and coronary artery calcification (CAC) by computed tomography. Results:
There was no association between CAC and carotid plaques(p = 0.8),maximum(p = 0.06)
or mean IMT (p = 0.2). No association was found between the presence of carotid plaques
and CRP (p = 0.4),TNF- (p = 0.8)orIL-10(p = 0.2).Likewise, individuals in the first three
quartiles for CRP, TNF- or IL-10 had similar values of CAC, mean and maximum IMT.
In contrast, individuals above the 75 th percentile for CRP or for TNF- had enhanced
maximum IMT (p = 0.017and p < 0.0001) and CAC (p = 0.026 and p = 0.01) and subjects
with IL-10 levels above the 75th percentile had lower maximum IMT (p = 0.027) and CAC
(p = 0.006) as compared with those below this percentile. There was no difference in mean
IMT for individuals above or below the 75th percentile for CRP, TNF-A or IL-10.
Conclusion: In very old individuals, CAC and maximum IMT were positively associated
with systemic inflammatory activity only in those above the 75th percentile. / Introdu????o: O n??mero de pessoas idosas (60 anos ou mais) cresce em todo o mundo, por dois
motivos: aumento da expectativa de vida e redu????o das taxas de fertilidade. Por outro lado, as
doen??as cardiovasculares, particularmente a aterosclerose, s??o a maior causa de morte,
especialmente na popula????o idosa. O envelhecimento provoca altera????es no sistema
imunol??gico que contribuem para uma maior incid??ncia de doen??as infecciosas e cr??nicodegenerativas.
N??veis basais de citocinas aumentados, representam um estado inflamat??rio
cr??nico sist??mico, chamado de Inflammaging. Na pessoa idosa, a redistribui????o da
calcifica????o nos tecidos ?? distinta dos valores preditivos da calcifica????o das art??rias
coron??rias. Desta forma, a associa????o de comorbidades provocadas pelo envelhecimento
inviabiliza a extrapola????o dos conhecimentos adquiridos em popula????es mais jovens.
Objetivo: investigar a associa????o entre n??veis s??ricos das citocinas: TNF- , IL-10 e Prote??na
C Reativa (PCR) com a calcifica????o coronariana em pessoas muito idosas. Materiais e
m??todos: Indiv??duos com idade entre 80 e 102 anos (n = 178). Foram avaliadas citocinas
plasm??ticas, prote??nas de fase aguda, espessura ??ntima-m??dia (IMT), presen??a de placas nas
art??rias car??tidas por ultrassom e calcifica????o da art??ria coron??ria (CAC) por tomografia
computadorizada. Resultados: N??o houve associa????o entre CAC e placas carot??deas (p = 0,8),
m??ximo (p = 0,06) ou m??dia IMT (p = 0,2). N??o foi encontrada associa????o entre a presen??a
de placas carot??deas e PCR (p = 0,4), TNF- (p = 0,8) ou IL-10 (p = 0,2). Da mesma forma,
os indiv??duos nos tr??s primeiros quartis de PCR, TNF- ou valores de IL-10 an??ncios
similares de CAC e IMT m??ximo. Os valores de CAC e IMT m??ximo, foram associados
positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima do percentil
75. Conclus??o: Em indiv??duos muito idosos, os valores de CAC e IMT m??ximo, foram
associados positivamente com a atividade inflamat??ria sist??mica apenas entre aqueles acima
do percentil 75.
| Identifer | oai:union.ndltd.org:IBICT/oai:bdtd.ucb.br:tede/2188 |
| Date | 17 April 2012 |
| Creators | Barros, Edilberto dos Santos |
| Contributors | C??rdova, Cl??udio Olavo de Almeida |
| Publisher | Universidade Cat??lica de Bras??lia, Programa Strictu Sensu em Educa????o F??sica, UCB, Brasil, Escola de Sa??de e Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UCB, instname:Universidade Católica de Brasília, instacron:UCB |
| Rights | info:eu-repo/semantics/openAccess |
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