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Previous issue date: 2011-07-08 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / This study aimed to apply, thermogravimetriy /derivative Thermogravimetriy
(TG/DTG), differential scanning calorimetry (DSC), Differential Thermal Analysis (DTA), to
conduct a comparative study on drug reference, generic and whose active principles are
similar captopril hydrochlorothiazide, ampicillin, paracetamol, aspirin and mebendazole sold
in local pharmacies. Samples of the active ingredients and dosage forms were also
characterized by absorption infrared spectroscopy (IR), X-ray diffraction (XRD) and
microscopy scanning electron (SEM). The TG / DTG curves showed a general similarity in
the thermal behavior of the samples, but also showed the influence of excipients on the
thermal stability. The DSC curve of the generic base hydrochlorothiazide showed no peak on
the fusion of the drug due to interference of lactose as a diluent, which causes interaction with
the active principle causing their degradation before the merger. The DSC curves of the drugs
consisting of paracetamol showed reproducibility at the melting point of the active and the
other thermal events. The DSC result of binary mixtures involving captopril / magnesium
stearate and mebendazole/magnesium stearate showed possible interactions or
incompatibilities evidenced by the displacement of the melting point of both drugs. The other
mixtures showed no change. The infrared spectra presented were very similar, indicating the
presence of functional groups characteristic of the constituents of the samples. The X-ray
diffraction showed peaks indicative of crystalline structure of the active ingredients as well as
some of the ingredients in the formulation of the drug and the micrographs indicate a general
heterogeneity in the size distribution of particles in the samples / Este trabalho teve como principal objetivo aplicar a Termogravimetria-Termogravimetria Derivada (TG-DTG), An?lise T?rmica Diferencial (DTA), Calorimetria
Explorat?ria Diferencial (DSC) para realizar um estudo comparativo em medicamentos de
refer?ncia, gen?rico e similar cujos princ?pios ativos s?o captopril, hidroclorotiazida,
ampicilina, paracetamol, ?cido acetil salic?lico e mebendazol comercializados nas farm?cias
locais. As amostras dos princ?pios ativos e das formas farmac?uticas tamb?m foram
caracterizadas por espectroscopia de absor??o na regi?o do infravermelho (IV), difratometria
de raios X (DRX) e microscopia eletr?nica de varredura (MEV). As curvas TG/DTG no geral
mostraram semelhan?as no comportamento t?rmico das amostras, no entanto mostrou tamb?m
a influ?ncia dos excipientes na estabilidade t?rmica dos princ?pios ativos. A curva DSC do
medicamento gen?rico a base de hidroclorotiazida n?o apresentou pico relativo ? fus?o do
f?rmaco devido ? interfer?ncia da lactose utilizada como diluente, que provoca intera??o com
o princ?pio ativo provocando a sua degrada??o antes da fus?o. As curvas DSC dos
medicamentos constitu?dos por paracetamol apresentaram reprodutibilidade no ponto de fus?o
do princ?pio ativo e nos demais eventos t?rmicos. Os resultados obtidos pela an?lise de DSC
das misturas bin?rias envolvendo o captopril/estearato de magn?sio e mebendazol/estearato de
magn?sio mostraram poss?veis intera??es ou incompatibilidades evidenciadas pelo
deslocamento do ponto de fus?o em ambos os f?rmacos. As demais misturas n?o mostraram
qualquer altera??o. Os espectros de infravermelho apresentaram-se bastante semelhantes
indicando a presen?a de grupos funcionais caracter?sticos dos constituintes das amostras. A
difra??o de raios X observa-se picos indicativos de estrutura cristalina dos princ?pios ativos
como tamb?m de alguns excipientes presentes na formula??o do medicamento e as
micrografias obtidas indicaram de uma forma geral heterogeneidade na distribui??o do
tamanho das part?culas nas amostras avaliadas
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17644 |
| Date | 08 July 2011 |
| Creators | Morais, Francisca Ediv?nia de |
| Contributors | CPF:44420773472, http://lattes.cnpq.br/9563490368583906, Silva, Ademir Oliveira da, CPF:16225422404, http://lattes.cnpq.br/3511004608337461, Souto, Carlos Roberto Oliveira, CPF:28467809949, http://lattes.cnpq.br/5481020781565211, Leles, Maria In?s Goncalves, CPF:22049258372, http://lattes.cnpq.br/1614912440064013, Fernandes, Nedja Suely |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Qu?mica, UFRN, BR, F?sico-Qu?mica; Qu?mica |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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