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Previous issue date: 2014-08-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This study used the Thermogravimetry (TG) and molecular absorption
spectroscopy in UV-visible region to determine the iron content in herbal medicinal
ferrous sulfate used in the treatment of iron deficiency anemia. The samples were
characterized by IR, UV, TG / DTG, DTA, DSC and XRD. The thermoanalytical
techniques evaluated the thermal stability and physicochemical events and showed that
the excipients interfere in the decomposition of the active ingredients. The results of
thermogravimetry showed that the decomposition temperature of the active principle
Fe2(SO4)3 (T = 602 ?C) is higher as compared to samples of tablets (566 586 ?C). In
the DTA and DSC curves were observed exothermic and endo events for samples of
medicines and active analysis. The infrared spectra identified key functional groups
exist in all samples of active ingredients, excipients and compressed studied, such as
symmetric and asymmetric stretching of OH, CH, S=O. The analysis by X-ray
diffraction showed that all samples had crystallinity and the final residue showed peaks
indicating the presence of silicon dioxide, titanium dioxide and talc that are excipients
contained in pharmaceutical formulations in addition to iron oxide. The results obtained
by TG to determine the iron content of the studied drugs showed a variance when
compared with those obtained by theoretical and UV-visible, probably due to formation
of a mixture of Fe2O3 and Fe2(SO4)3. In one tablet was obtained FE content of 15.7 %
and 20.6 % for TG by UV-visible, the sample EF 2 was obtained as a percentage of 15.4
% and 21.0 % for TG by UV-visible . In the third SF samples were obtained a content
of 16.1 % and 25.5 % in TG by UV-visible, and SF 4 in the percentage of TG was 16.7
% and 14.3 % UV-visible / O presente trabalho utilizou a termogravimetria (TG) e a espectroscopia de
absor??o molecular na regi?o UV-vis?vel para determinar o teor de ferro em
medicamentos ? base de sulfato ferroso usados no tratamento da anemia ferropriva. As
amostras foram caracterizadas por IV, UV, TG/DTG, DTA, DSC e DRX. As t?cnicas
termoanal?ticas avaliaram a estabilidade t?rmica e os eventos f?sico-qu?micos e
mostraram que os excipientes interferem na decomposi??o do princ?pio ativo. Os
resultados da Termogravimetria indicaram que a temperatura de decomposi??o do
Fe2(SO4)3 (T = 602 ?C) ? superior em compara??o as amostras dos comprimidos (566 a
586 ?C). Nas curvas DTA e DSC foram observados eventos endo e exot?rmicos para as
amostras dos medicamentos e princ?pio ativo analisado. Os espectros de infravermelho
identificaram os principais grupos funcionais existentes em todas as amostras de
princ?pios ativos, excipientes e comprimidos estudados, tais como estiramentos
sim?tricos e assim?tricos dos grupos O-H, C-H, S=O. As an?lises por difra??o de raios-
X mostraram que todas as amostras apresentaram cristalinidade e que os res?duos finais
mostraram picos indicativos da presen?a de di?xido de sil?cio, di?xido de tit?nio e talco
que s?o excipientes contidos nas formula??es farmac?uticas, al?m do ?xido de ferro. Os
resultados obtidos por TG para determinar o teor de ferro dos medicamentos estudados
mostraram uma varia??o quando comparados aos obtidos pelo UV-vis?vel e o te?rico,
provavelmente devido a forma??o de uma mistura de Fe2O3 e Fe2(SO4)3. No
comprimido FE 1 foi obtido um teor de 15,7 % pela TG e 20,6 % pelo UV-vis?vel, na
amostra FE 2 obteve-se um percentual de 15,4 % pela TG e 21,0 % pelo UV-vis?vel.
Nas amostras FE 3 obteve-se um teor de 16,1 % na TG e 25,5 % pelo UV-vis?vel, e em
FE 4 o percentual na TG foi de 16,7 % e no UV-vis?vel 14,3 %
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17767 |
| Date | 19 August 2014 |
| Creators | Silva, Marcia Lima da |
| Contributors | CPF:44420773472, http://lattes.cnpq.br/9563490368583906, Huitle, Carlos Alberto Martinez, CPF:01139059980, http://lattes.cnpq.br/2485073932883264, Moura, Maria de F?tima Vit?ria de, CPF:31482015404, http://lattes.cnpq.br/2959800336802498, Souza, Luiz Di, CPF:01925100880, http://lattes.cnpq.br/0589648773241934, Fernandes, Nedja Suely |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Qu?mica, UFRN, BR, F?sico-Qu?mica; Qu?mica |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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