Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-02-05T22:05:48Z
No. of bitstreams: 1
LeonardoDeSaCosta_DISSERT.pdf: 2101335 bytes, checksum: ac42734e9bbfbba5815b32c66600ff2b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-02-15T23:04:07Z (GMT) No. of bitstreams: 1
LeonardoDeSaCosta_DISSERT.pdf: 2101335 bytes, checksum: ac42734e9bbfbba5815b32c66600ff2b (MD5) / Made available in DSpace on 2016-02-15T23:04:07Z (GMT). No. of bitstreams: 1
LeonardoDeSaCosta_DISSERT.pdf: 2101335 bytes, checksum: ac42734e9bbfbba5815b32c66600ff2b (MD5)
Previous issue date: 2014-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Este trabalho teve a finalidade de promover a s?ntese, caracteriza??o e de propor uma
estrutura molecular para os compostos de coordena??o envolvendo a furosemida (?cido 4-
cloro-2-(2-furilmetilamino)-5-sulfamoil-benz?ico), com os ?ons met?licos Ni+2, Zn+2 e Co+2
.
Os compostos foram obtidos em meio metan?ico por evapora??o do solvente ap?s o
procedimento da s?ntese. Para caracteriza??o dos compostos de coordena??o, foram feitas as
determina??es dos teores de metais por complexometria com EDTA, espectroscopia na regi?o
do infravermelho (FTIR), solubilidade dos compostos em diversos solventes, an?lise
termogravim?trica (TG), calorimetria explorat?ria diferencial (DSC), an?lise t?rmica
diferencial (DTA) e a determina??o dos teores de carbono, nitrog?nio e hidrog?nio (CHN). Os
resultados da espectroscopia na regi?o do infravermelho sugerem que o ligante se coordene de
forma bidentada, com os ?ons met?licos. As intera??es com os centros met?licos ocorrem pela
coordena??o do ?tomo de nitrog?nio do grupo amino e pelo ?tomo de oxig?nio do ?cido
carbox?lico da estrutura da furosemida. Com os resultados dos teores de metais, an?lise
elementar (CHN) e an?lise t?rmica, foram poss?veis propor as estruturas dos complexos. Os
valores de condutividade molar em acetonitrila indicam que os complexos apresentam
comportamento de n?o eletr?lito em solu??o. Os compostos apresentam alta solubilidade em
metanol e acetonitrila, j? em ?gua s?o parcialmente insol?veis. Atrav?s dos resultados das
an?lises t?rmicas (TG, DSC, DTA), obteve-se o comportamento t?rmico dos compostos
como: etapas de desidrata??o, estabilidade t?rmica, decomposi??o e as energias envolvidas. / This work aimed to promote the synthesis, characterization and propose a plausible
molecular structure for coordination compounds involving furosemide (4-Chloro-2-(2-
furylmethylamino)-5-sulfamoyl-benzoic acid) with the metal ions Ni+2, Zn+2 and Co+2. The
compounds were obtained in methanoic medium by evaporation of the solvent after the
synthesis procedure. For characterization of coordination compounds determining the levels
of metals by EDTA complexometry, infrared spectroscopy (FTIR), solubility of compounds
in various solvents, thermogravimetry (TG), differential scanning calorimetry (DSC),
differential thermal analysis were made (DTA), determination of the carbon , hydrogen and
nitrogen (CHN). The results of infrared spectroscopy in the region suggest that the organic
ligand is coordinated in a bidentate fashion to the metal ions, the metal center interactions to
occur by the coordination of the nitrogen atom of the amino group and the oxygen atom of the
carboxylic acid of the structure of furosemide. With the results of the levels of metal,
elemental analysis (CHN) and thermal analysis has been possible to propose the structure of
the ligand. The values of the molar conductivity of the complex in acetonitrile behavior
suggest the non acetonitrile electrolyte solution. With the solubility tests it was found that the
compounds have high solubility in methanol and acetonitrile, as are partially insoluble in
water. From the results of thermal analysis (TG, DSC, DTA), it was possible to obtain the
thermal behavior of the compounds as stages of dehydration, thermal stability, decomposition
and the energies involved.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19773 |
| Date | 27 February 2014 |
| Creators | Costa, Leonardo de S? |
| Contributors | 31482015404, http://lattes.cnpq.br/2959800336802498, Silva, Ademir Oliveira da, 16225422404, http://lattes.cnpq.br/3511004608337461, Silva, Henrique Eduardo Bezerra da, 48102288434, http://lattes.cnpq.br/2722164837738303, Oliveira, ?tom Anselmo de, Moura, Maria de F?tima Vit?ria de |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM QU?MICA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
Page generated in 0.0021 seconds