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Previous issue date: 2008 / Introdução: Com o advento da terapia anti-retroviral de alta
potencia (TARV), a expectativa de vida do paciente com HIV/AIDS
aumentou. A lipoatrofia facial é uma complicação comum nesses
pacientes que, muitas vezes, os submete ao estigma e à segregação,
assim como afeta negativamente a qualidade de vida. Objetivo: verificar
o impacto do tratamento da lipoatrofia facial com o polimetilmetacrilato
(PMMA) na qualidade de vida de pacientes com AIDS em tratamento
com anti-retrovirais, medido por quatro questionários que traduzem
qualidade de vida. Métodos: 40 pacientes com AIDS sob TARV com
diagnóstico de lipoatrofia facial fizeram parte deste estudo. Os primeiros
20 pacientes foram para o Grupo Tratamento, e suas faces foram tratadas
com PMMA. Os outros 20 pacientes foram alocados em um Grupo
Controle, e foram tratados apenas seis meses depois, após o término do
presente estudo. No momento zero, quatro questionários de qualidade de
vida foram aplicados, como Medical Outcomes Study 36-Item ShortForm
Health Survey (Short Form-36), a Escala de Auto-Estima
Rosenberg/UNIFESP-EPM, Body Shape Questionnaire (BSQ) e o
Inventário de Depressão de Beck. Esses questionários foram novamente
aplicados seis meses depois para ambos os grupos, termino do estudo. Os
escores obtidos foram comparados intragrupo e intergrupos através dos
testes não paramétricos de Mann Whitney e Wilcoxon. Resultados: a
variação dos escores obtidos no Grupo Tratamento para todos os
questionários em todos os domínios foi significativamente diferente para
melhor, quando confrontados com o Grupo Controle. Conclusão: Houve
melhora na qualidade de vida do paciente com AIDS e lipoatrofia facial,
quando tratados com PMMA. / Introduction: Life expectancy increased in patients
infected with HIV/AIDS with the advent of highly active antiretroviral
therapy. Facial lipoatrophy is a common complication in these patients,
eventually leading to stigma, segregation and a negative impact in
quality of life. Objective: to evaluate the impact of the treatment of
facial lipoatrophy with poly-methyl-metha-acrylate (PMMA) in the
quality of life of patients with aids, as measured by four questionnaires
that address quality of life. Methods: Forty consecutive aids patients on
HAART referred for facial lipoatrophy treatment were enrolled in this
study. The first 20 were allocated to the intervention group and were
treated with tissue augmentation with PMMA. The other 20 were
allocated to the control group, which received treatment only after six
months. At moment zero, four questionnaires were applied to all patients
in both groups, namely, the Medical Outcomes Study 36-Item ShortForm
Health Survey (SHORT FORM-36), The Self-Esteem Scale
Rosemberg/UNIFESP-EPM, Body Shape Questionnaire and Beck
Depression Inventory. The questionnaires were applied again in six
months, that is, post-treatment in the intervention group, and pretreatment
in the conttrol group. Scores were compared within and
between groups with Mann-Whitney’s and Wilcoxon’s tests. Result:
The variation in scores within the intervention group for all domains of
all four instruments was significantly different for better when compared
to that within the control group. Conclusion: We detected improvement
in the quality of life of patients with aids and facial lipoatrophy, when
they were treated with PMMA, as opposed to an untreated control group. / BV UNIFESP: Teses e dissertações
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/24182 |
| Date | January 2008 |
| Creators | Warde Filho, Mario Jorge [UNIFESP] |
| Contributors | Universidade Federal de São Paulo (UNIFESP), Gragnani, Alfredo [UNIFESP] |
| Publisher | Universidade Federal de São Paulo (UNIFESP) |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | 124 f. |
| Source | reponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP |
| Rights | info:eu-repo/semantics/openAccess |
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