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Previous issue date: 2013-03-21 / Endodontic aims to prevent and treat diseases of the pulp and periapical tissues. Although the maintenance of pulp vitality is of paramount importance, conservative treatments are not commonly recommended for teeth with pulp exposure by caries. In these situations, conservative treatment is usually indicated for young teeth with open apex. For all the other cases a radical treatment is indicated, the root canal treatment. The reluctance in performing a conservative treatment in a permanent tooth with exposed pulp by caries is due to the difficulty of an accurate diagnosis, as to the condition of pulp inflammation (reversible or irreversible) and in the absence of a compound that promote this tissue to return to homeostasis . Thus, the present study evaluated histologically the effects of Emdogain ? (EMD) and its vehicle, propylene glycol alginate (PGA), in rat infected dental pulp.For this, the pulp chambers of the right lower molars of 24 male Wistar rats were perforated and the cavities were left open to the oral environment for 24 h. Then, the exposed pulp surfaces were direct capped with either EMD or its carrier PGA (n=6), and the cavities were restored with glass-ionomer cement. After the experimental period of 48 hours and 30 days, the animals were euthanized and the dissected mandibles were histologically evaluated. The results showed that a hard tissue barrier was absent in the EMD and PGA groups in the two evaluation periods. At 48 h the groups exhibited similar pulp behavior. At 30 days, the group capped with EMD showed a reduced inflammatory process limited to the exposed area, and degenerative changes on the pulp tissue throughout the length of the root canals. Thus, our results suggest that EMD was not effective on the providing proper wound healing of infected rat molar pulp / A Endodontia tem como objetivo a preven??o e o tratamento das doen?as da polpa e dos tecidos periapicais. Embora a manuten??o da vitalidade pulpar seja de fundamental import?ncia, tratamentos conservadores n?o s?o comumente indicados para dentes com polpa exposta por c?rie. Nestas situa??es, o tratamento conservador costuma ser indicado somente para dentes jovens com ?pice aberto. Para os demais casos indica-se o tratamento radical, a endodontia. A relut?ncia em se realizar um tratamento conservador em um dente permanente com polpa exposta por cavidade profunda de c?rie est? na dificuldade de um diagn?stico preciso quanto ? condi??o pulpar de inflama??o revers?vel e irrevers?vel e na falta de uma subst?ncia que possa fazer esse tecido retornar a homeostase.Neste sentido, o presente estudo avaliou histologicamente os efeitos do Emdogain? (EMD) e o seu ve?culo, propileno glicol alginato (PGA) em polpas dent?rias infectadas de ratos. Para isto foram utilizados 24 molares inferiores de ratos Wistar machos com 8 semanas de idade. A c?mara pulpar foi perfurada e as cavidades ficaram expostas ? cavidade oral por um per?odo de 24 h. Ap?s, as superf?cies pulpares foram capeadas utilizando Emdogain? (n=6) ou PGA (n=6) como controle, e em seguida foram restauradas com cimento de ion?mero de vidro. Passados os tempos experimentais de 48 h e 30 dias, os animais foram eutanasiados e as mand?bulas foram dissecadas para avalia??o histol?gica.Os resultados encontrados mostraram que n?o houve forma??o de barreira de tecido duro em nenhum dos grupos e tempos experimentais avaliados. No per?odo experimental de 30 dias, o grupo EMD apresentou reduzido processo inflamat?rio, este sendo limitado ao s?tio de exposi??o, e altera??es degenerativas em toda a extens?o do canal radicular foram predominantes neste grupo. Sendo assim, estes resultados sugerem que o EMD n?o foi efetivo em promover adequado reparo tecidual em polpas infectadas de ratos
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/1217 |
| Date | 21 March 2013 |
| Creators | Cucco, Carolina |
| Contributors | Figueiredo, Jos? Antonio Poli de |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Odontologia, PUCRS, BR, Faculdade de Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -8096554818733665164, 500, 600, 4673435736271820140 |
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