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Previous issue date: 2017-04-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This study aims to describe the medications used by people aged 55 years and over enrolled in the ?Programa de Envelhecimento Cerebral? (PENCE) of the Family Health Strategy of Porto Alegre. It will also describe among these patients the occurrence of polypharmacy, the use of potentially inappropriate medications and its association with patients? socioeconomic, lifestyle and health variables, especially the signs and symptoms of depression and cognitive deficit. A cross-sectional population-based study conducted from January 2013 to December 2015, approved by the Research Ethics Committee of PUCRS (n? 826.858). The prevalence of polypharmacy was reported in 35.7% of the population and was the most common drug amount of all age groups, including the younger individuals (55-59 years) (28.1%). After adjustment for socioeconomic and health variables, women (OR 2.46; 95% CI 1.71-3.53), 75-79 years (OR 3.13; 95% CI 1.68-5.83), 1-3 years of study (OR 2.57; 95% CI 1.43-4.59), ex-smokers (OR 1.89; 95% CI 1.29-2.78), poor or very poor self-perceived health (OR 6.43; 95% CI 3.20-12.90), chronic conditions (cardiovascular-related) and depression symptoms were strongly associated with polypharmacy. The prevalence of PIM in the total population was 65.4%, representing a common finding in all age groups, including younger individuals (55-59 years) (60.0%). Former smokers (OR 1.06; 95% CI 1.00-1.12) and current smokers (OR 1.10; 95% CI 1.01-1.18), regular self-perception of health (OR 1.08; 95% CI 1.02-1.15), use three or four medications (OR 1.88; 95% CI 1.65-2.15), and individuals with signs and symptoms of cognitive deficit (OR 1.14; 95% CI 1.03-1.26) and depression (OR 1.12; 95% CI 1.04-1.21) were significantly associated with PIM. Polypharmacy (OR 2.80; 95% CI 2.48-3.16) had the strongest association. Polypharmacy and MPI are prevalent in middle-aged individuals, a population that is poorly researched, and the elderly. The present study proposed an advance in pharmacoepidemiological studies, analyzing some gaps in the literature related to middle-aged adults with unfavorable socioeconomic characteristics, such as low income and schooling. / Este estudo tem por objetivo descrever os medicamentos utilizados por pessoas com 55 anos ou mais, cadastradas no Programa de Envelhecimento Cerebral (PENCE) da Estrat?gia Sa?de da Fam?lia de Porto Alegre, a ocorr?ncia de polifarm?cia, o uso de medicamentos potencialmente inapropriados e a associa??o com vari?veis socioecon?micas, h?bitos de vida e sa?de, principalmente os sinais e sintomas de depress?o e de d?ficit cognitivo. Estudo transversal de base populacional, realizado entre janeiro de 2013 a dezembro de 2015, aprovado pelo Comit? de ?tica em Pesquisa da PUCRS (n? 826.858). A preval?ncia de polifarm?cia na popula??o total foi de 35,7%, representando um achado comum a todas as faixas et?rias, incluindo os indiv?duos mais jovens (55-59 anos) (28,1%). Ap?s o ajuste para as vari?veis socioecon?micas e de sa?de, as mulheres (OR 2,46; IC 95% 1,71-3,53) e os indiv?duos com 75-79 anos (OR 3,13; IC 95% 1,68-5,83), 1-3 anos de estudo (OR 2,57; IC 95% 1,43-4,59), ex-fumantes (OR 1,89; IC 95% 1,29-2,78), com pior autopercep??o de sa?de (OR 6,43; IC 95% 3,20-12,90), com doen?as cr?nicas (principalmente as cardiovasculares) e com sintomas depressivos foram fortemente associados ? polifarm?cia. A preval?ncia de PIM na popula??o total foi de 65,4%, representando um achado comum a todas as faixas et?rias, incluindo os indiv?duos mais jovens (55-59 anos) (60,0%). Os ex-fumantes (OR 1,06; IC 95% 1,00-1,12) ou atuais (OR 1,10; IC 95% 1,01-1,18), com autopercep??o de sa?de regular (OR 1,08; IC 95% 1,02-1,15), que faziam uso de tr?s ou quatro medicamentos (OR 1,88; IC 95% 1,65-2,15) e com sinais e sintomas de d?ficit cognitivo (OR 1,14; IC 95% 1,03-1,26) e depress?o (OR 1,12; IC 95% 1,04-1,21) foram significativamente associados com o maior consumo de MPI, sendo a polifarm?cia (OR 2,80; IC 95% 2,48-3,16) a vari?vel com a mais forte rela??o. Polifarm?cia e MPI s?o prevalentes em indiv?duos de meia-idade, uma popula??o que ? pouco pesquisada, e em idosos. O presente estudo prop?s um avan?o nos estudos farmacoepidemiol?gicos, analisando algumas lacunas na literatura relacionada aos adultos de meia-idade com caracter?sticas socioecon?micas desfavor?veis, como baixas renda e escolaridade.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/7629 |
| Date | 28 April 2017 |
| Creators | Sgnaolin, Vanessa |
| Contributors | Cataldo Neto, Alfredo |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Gerontologia Biom?dica, PUCRS, Brasil, Instituto de Geriatria e Gerontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 4438661476953179033, 500, 500, 500, 600, 2296420844541114010, -969369452308786627, 2075167498588264571 |
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