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Previous issue date: 2018-01-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Ulcerative lesions are some of the most common injuries of the oral mucosa. Damage
to the epithelial barrier results in discomfort, which may interfere with oral hygiene,
chewing, swallowing and speech. The management of these lesions basically aims to
optimize and accelerate tissue repair, in addition to reducing its symptomatology.
However, there is no option considered gold standard for the treatment of traumatic
mouth ulcers. Cannabidiol (CBD) is the main non-psychomimetic component of
Cannabis sativa. It exerts potent antiinflammatory, antioxidant and analgesic effects
when tested in various pathological conditions. The present dissertation is structured in
the form of 2 scientific papers. The first article consists of a literature review to evaluate
the different mechanisms of action of CBD that may be involved in the repair of
ulcerative lesions, suggesting that this drug is promising for the treatment of oral
inflammatory disorders. The second article is a report of an experimental study
conducted in an animal model, to assess the effect of 5 and 10 mg/kg CBD on the
repair of an ulcerative lesion induced on the ventral tongue of 60 Wistar rats after 3 and
7 days. Treatment with CBD decreased inflammatory scores after 3 days (p < 0.05), but
was unable to clinically influence the size of ulcerative lesions. Thus, it is concluded that
CBD has an inflammation modulating effect and may represent a promising alternative
in the management of oral wounds. / As les?es ulceradas correspondem ?s enfermidades mais frequentes da mucosa bucal.
O dano ? barreira epitelial resulta em desconforto, podendo interferir na higiene oral,
mastiga??o, degluti??o e fala. O manejo dessas les?es objetiva basicamente otimizar e
acelerar o reparo tecidual, al?m de diminuir a sintomatologia dolorosa. No entanto, n?o
est? dispon?vel atualmente uma alternativa considerada o padr?o-ouro para o
tratamento das ?lceras traum?ticas bucais. O canabidiol (CBD) ? o principal
componente n?o-psicomim?tico da Cannabis sativa e desempenha potentes efeitos
anti-inflamat?rios, antioxidantes e analg?sicos em diversas condi??es patol?gicas. A
presente disserta??o est? estruturada na forma de 2 artigos cient?ficos. O primeiro
consiste em uma revis?o de literatura, cujo objetivo foi avaliar os diferentes
mecanismos de a??o do CBD que possam estar envolvidos no reparo de les?es
ulceradas traum?ticas, sugerindo o car?ter promissor desta droga na terapia de
dist?rbios inflamat?rios orais. O segundo trata de um estudo experimental desenvolvido
em modelo animal, com objetivo de avaliar cl?nica e histologicamente o efeito da
administra??o intraperitoneal do CBD, nas doses de 5 e 10 mg/kg, por 3 e 7 dias, no
reparo de les?o ulcerada induzida no ventre lingual de 60 ratos Wistar. O tratamento
com CBD foi capaz de diminuir os escores inflamat?rios das les?es ap?s 3 dias (p <
0,05), contudo n?o foi suficiente para interferir no tempo de cicatriza??o das ?lceras.
Dessa forma, concluiu-se que o CBD ? capaz de modular o processo inflamat?rio em
les?es ulceradas orais, podendo representar uma alternativa promissora no manejo
dessa condi??o.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/7905 |
| Date | 22 January 2018 |
| Creators | Klein, Mariana |
| Contributors | Figueiredo, Maria Antonia Zancanaro |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Odontologia, PUCRS, Brasil, Escola de Ci?ncias da Sa?de |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -8096554818733665164, 500, 500, 600, -2070498469879244349, 2075167498588264571 |
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