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Previous issue date: 2015-09-28 / Essential oils are complex mixtures of various isolates of plant secondary metabolites. Due to the increased use of these aromatic compounds, research has been developed, and the development of new products. This study analyzed the antimicrobial, cytotoxic and immunomodulatory activities in addition to the phytochemical profile of essential oils Achyrocline satureoides and Ageratum conyzoides. The micro-organisms most sensitive to oils were Staphylococcus aureus CCMB 262 and Candida kruzei CCMB 287. The essential oil of A. conyzoides was considered non-toxic in the tested conditions. In the assessment of the immune response induced by oils, although they were not statistically significant differences between the concentrations tested and control, it was observed that the essential oils inhibited the production of IL-8 and IL-12 cytokines with exception of the species A. satureoides at a concentration of 100 mg / mL. This behavior may suggest the capacity reduction of the inflammatory response. The chromatographic analysis of essential oils of A. satureoides demonstrated a chemical profile consistent with the literature where the major components were ?-Pinene, E-caryophyllene, ?-copaene, ?-humulene, d-cadinene. Since the analysis of oils A. conyzoides showed conflicting results in the literature which suggests a new chemotype, since the presence of precocenos the chemical analysis was not observed. / Os ?leos essenciais s?o misturas complexas de metab?litos secund?rios isolados de diversas plantas. Devido ao aumento do uso destes compostos arom?ticos, pesquisas v?m sendo desenvolvidas, al?m do desenvolvimento de novos produtos. O presente trabalho analisou as atividades antimicrobiana, citot?xica e imunomoduladora, al?m do perfil fitoqu?mico de ?leos essenciais de Achyrocline satureoides e Ageratum conyzoides. Os micro-organismos mais sens?veis aos ?leos foram Staphylococcus aureus CCMB 262 e Candida kruzei CCMB 287. O ?leo essencial de A. conyzoides foi considerado at?xico nas condi??es testadas. Em rela??o ? avalia??o da resposta imune induzida pelos ?leos, apesar de n?o terem sido encontradas diferen?as estatisticamente significantes entre as concentra??es testadas e o controle, p?de-se observar que os ?leos essenciais inibiram a produ??o das citocinas IL-8 e IL-12, com exce??o da esp?cie A. satureoides na concentra??o de 100 ?g/mL. Este comportamento pode sugerir a capacidade de redu??o da resposta inflamat?ria. As an?lises cromatogr?ficas dos ?leos essenciais de A. satureoides demonstrou um perfil qu?mico em concord?ncia com a literatura onde os componentes majorit?rios foram ?-Pineno, E-Cariofileno, ?-Copaeno, ?-Humuleno, d-Cadineno. J? as an?lises dos ?leos de A. conyzoides apresentou resultados divergentes da literatura o que nos sugere um novo quimiotipo, uma vez que n?o foi observada a presen?a de precocenos nas an?lises qu?micas.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.uefs.br:8080:tede/283 |
| Date | 28 September 2015 |
| Creators | Gon?alves, Jacqueline Miranda |
| Contributors | Uetanabaro, Ana Paula Trovatti |
| Publisher | Universidade Estadual de Feira de Santana, Doutorado Acad?mico em Biotecnologia, UEFS, Brasil, DEPARTAMENTO DE CI?NCIAS BIOL?GICAS |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UEFS, instname:Universidade Estadual de Feira de Santana, instacron:UEFS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | -6815269229789791543, 600, 600, 600, 5026123383450589282, -1634559385931244697 |
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