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Transient deposition of particles with applications to inhaled pharmaceutical aerosols

Most current models for the deposition of aerosol particles in the human lung
are based on a Lagrangian reference frame, which is ill-suited for modeling
transient eects. Deposition models based on an Eulerian reference frame are
much better at capturing instantaneous time-dependent eects, though they
are dicult to create. In the interest of developing such models, mathematical
techniques were used to describe the velocity elds of simple particle
ows.
Analytic expressions describing the time-dependent
ow of particles through a
curved pipe were created and implemented numerically. The numerical simulations
were used to determine which
ow regimes required the use of Eulerian
modelling for deposition prediction.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/1813
Date06 1900
CreatorsOphus, Philip S
ContributorsLange, Carlos (Mechanical Engineering), Finlay, Warren (Mec. Eng.), Olfert, Jason (Mec. Eng.), Hicks, Faye (Civil Eng.)
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeThesis
Format1544544 bytes, application/pdf

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