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Bioinformatics and Biological Databases: 1) Sigma-54 Promoter Database – A Database of Sigma-54 Promoters Covering a Wide Range of Bacterial Genomes 2) ClusterMine360 – A Database of PKS/NRPS Biosynthesis

The Sigma-54 Promoter Database contains computationally predicted sigma-54 promoters from
over 60 prokaryotic species. Organisms from all major phyla were analysed and results were
made available online at http://www.sigma54.ca. This database is particularly unique due to its
inclusion of intragenic regions, grouping of data by COG and COG category, and the ability to
summarize results either by phylum or database-wide.
ClusterMine360 (http://www.clustermine360.ca/) is a database of microbial polyketide and nonribosomal peptide gene clusters. It takes advantage of crowd-sourcing by allowing members of the community to make contributions while automation is used to help achieve high data
consistency and quality. The database currently has over 200 gene clusters from over 185
compound families. It also features a unique sequence repository containing over 10,000
PKS/NRPS domains. The sequences are filterable and downloadable as individual or multiple
sequence FASTA files. This database will be a useful resource for members of the PKS/NRPS
research community enabling them to keep up with the growing number of sequenced gene
clusters and rapidly mine these clusters for functional information.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OOU.#10393/23648
Date14 January 2013
CreatorsConway, Kyle
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeThèse / Thesis

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