Absence or impairment of functional communication is a fundamental deficit in Autism Spectrum Disorder (ASD). The specific factors that contribute to a great variety of speech and language impairments are still unknown but have a neurobiological substratum. We investigated the brain control of speech production mechanism in children with ASD using Magnetoencephalography (MEG). MEG is a neuroimaging modality with high temporal resolution that records neural activation in real time. A group of children with ASD and age- and sex- matched controls performed simple oromotor (open and close mouth) and speech tasks (one-syllable and multi-syllable phoneme production). Atypical and significantly different brain neural activation in motor (BA 6 and BA 4) areas and speech control (BA 47, BA 22) areas were noted in children with ASD compared to typically developing controls. The present thesis provides new evidence contributing to the understanding of speech and language production in individuals with autism.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/44070 |
| Date | 19 March 2014 |
| Creators | Valica, Tatiana |
| Contributors | Anagnostou, Evdokia, Pang, Elizabeth |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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