LAG-3 is an immune inhibitory marker. These immune inhibitory markers function to reduce the capability of immune cells to elicit a proper immune response and to help maintain tolerance. During an acute infection, these markers assist in controlling the immune system, however, during a chronic infection these markers prevent the immune response from persisting to effectively fight the disease. Contrary to other immune inhibitory markers, LAG-3 is not highly expressed on T cells during chronic viral infections, such as HIV.
The majority of information available on LAG-3 has been gained from murine models and cell lines. This thesis uses primary human T cells in order to observe rapid expression of surface LAG-3 from a pre-formed intracellular store and cleavage of these surface molecules into soluble variants by matrix metalloprotease cleavage. LAG-3 and sLAG-3 expression is compared with CD69 and cytokine expression to help understand the early immune response. / October 2015
| Identifer | oai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/30708 |
| Date | 01 September 2015 |
| Creators | Stalker, Andrew |
| Contributors | Fowke, Keith (Medical Microbiology), Yang, Xi (Medical Microbiology) Ho, Emmanuel (Pharmacy) |
| Source Sets | University of Manitoba Canada |
| Detected Language | English |
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