In normal pregnant women, reactivation of Epstein-Barr virus (EBV) frequently occurs. Cellular immune response is apparently supperessed, but the antibodies cross the placenta and protect the infant against primary infection for many months. The Epstein¡VBarr virus (EBV) encoded latent membrane protein 1 (LMP1) which plays a crucial role in the long-term persistence of this virus within the cells of the immune system. Not only is this protein critical for the transformation of resting B cells by EBV, it also displays pleiotropic effects on various cellular proteins expressed in the host cell. These include upregulation of express- ion of B cell activation antigens, adhesion molecules, and various components of the antigen processing pathway. Here we test 45 human placenta samples for LMP1 of Epstein¡VBarr virus (EBV) by RT-PCR and immunohistochemistry. Eight of forty five (18%) are positive , and thirty seven of forty five (82%) are negative for LMP expression. It is noticed that all LMP protein expression were shown on the maternal side but not on the fetal side. The placenta may serve as a protection barrier for fetus against Epstein-Barr virus infection.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0726102-113613 |
| Date | 26 July 2002 |
| Creators | huang, Zoo-Hzu |
| Contributors | Chung-Lung Cho, Jong-Kang Liu, Shui-nin Li |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0726102-113613 |
| Rights | unrestricted, Copyright information available at source archive |
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