ABSTRACT
The marine sponge Xestospongia sp. was collected along seashore area of Lan Yu in Taiwan. Fractionation of the MeOH/CHCl3 extract by using silica gel colum chromatography yielded eight polycycle quinones and hydroquinones ,namely halenaquinone (1)¡B halenaquinol(2)¡B14-methoxyxestoquinone (3)¡B15-methoxyxeatoquinone (4)¡B xestoquinone (5)¡B15-chloro-hydroxestoquinone (6) ¡Badociaquinone A (7)¡B adociaqunone B (8) . The structures of these compounds were idenified by UV¡BIR¡BMS¡B 1D and 2D NMR .
Biological screening revealed that compounds 7 and 8 possessed in vitro cytotoxicities against two tumor cell lines (KB 16, HEPA-3B). The ED50 value of compound 7 showed cytotoxicities against KB 16 and HEPA-3B tumor cell lines were 0.26 £gg/mL and < 0.1 £gg/mL, respectively. The ED50 value of compound 8 were < 0.1 £gg/mL and 1.8 £gg/mL .
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0829100-151925 |
| Date | 29 August 2000 |
| Creators | Lo, Kuang-Liang |
| Contributors | none, none, none |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829100-151925 |
| Rights | restricted, Copyright information available at source archive |
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