During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented
magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in
Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II
of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and
2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South
America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from positive
selection. However, the 2010 and 2011 DENV-2 did not replicate to higher titers in monocyte-derived dendritic cells and
did not infect or disseminate in a higher proportion of Aedes aegypti than DENV-2 isolates previously circulating in Loreto.
These results suggest that factors other than enhanced viral replication played a role in the severity of this outbreak.
| Identifer | oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/605309 |
| Date | 07 July 2014 |
| Creators | Williams, M., Mayer, S. V., Johnson, W. L., Chen, R., Volkova, E., Vilcarromero, S., Widen, S. G., Wood, T. G., Suarez Ognio, L., Long, K. C., Hanley, K. A., Morrison, A. C., Vasilakis, N., Halsey, E. S. |
| Publisher | The American Society of Tropical Medicine and Hygiene |
| Source Sets | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/article |
| Source | Universidad Peruana de Ciencias Aplicadas (UPC), Repositorio Académico - UPC |
| Rights | http://creativecommons.org/licenses/by-nc-nd/4.0/, info:eu-repo/semantics/openAccess |
| Relation | http://www.ajtmh.org/cgi/doi/10.4269/ajtmh.13-0600 |
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